Microdosing GLP-1s: Why Are People Trying It?
GLP-1 meds have been around for diabetes and weight loss—but lately, there’s a new trend: microdosing. That’s taking smaller doses than usual. Here’s why people are giving it a try:
Slow and Steady Wins the Race
Big doses can lead to fast weight loss, but sometimes that pace is hard to keep up with. Microdosing lets you lose weight slowly and sustainably, which often sticks better in the long run.
Curb Cravings Without Going Overboard
Even at lower doses, GLP-1s can help reduce cravings and support your hormones. That means you can still get benefits without feeling like your life is completely disrupted.
Potential Health Boosts
Early research suggests GLP-1s may lower inflammation, helping your overall health. Microdosing might give you some of these perks with fewer side effects.
Small, Smart Wins
Some people use microdoses off-label for modest weight loss or to support metabolism. It’s not officially approved for this, but many find it helpful when done thoughtfully.
Closing Thought:
Microdosing GLP-1s is all about gentler, more manageable results—less intense, more sustainable, and still beneficial. Curious? Talk to Jen NP to see if it could fit into your plan safely.
References:
Obes Rev. 2023 Mar;24(3):e13543. doi: 10.1111/obr.13543. Epub 2022 Dec 29. https://pubmed.ncbi.nlm.nih.gov/36579723/
Biochem Pharmacol . 2024 Dec;230(Pt 3):116623. doi: 10.1016/j.bcp.2024.116623. Epub 2024 Nov 13. https://pubmed.ncbi.nlm.nih.gov/39542180/
Menopause 31(4):p 266-274, April 2024. | DOI: 10.1097/GME.0000000000002310
* The research to date focuses on “on-label” use. “Microdosing” and use in non-diabetic and overweight (not obese) is considered off-label use and so the results cannot be taken to apply to all populations. Compounded GLP1 and GLP1A medications are not FDA approved. These medications are made in compounding pharmacies that must adhere to strict FDA regulations however.